【摘要】 目的探讨颈动脉粥样硬化患者体内高敏C反应蛋白(hs-CRP)水平变化的临床意义。方法选择2004年1~11月住院的145例颈动脉粥样硬化患者,剔除入院前4周有急性感染病史者。采用彩色多普勒超声诊断仪检测颈动脉,根据其病变情况分为I组(正常组,31例)、II组(内膜增厚组,48例)、III组(单个斑块组,27例)及IV组(多个斑块组,39例)。应用酶标多克隆抗体夹心法测定各组hs-CRP值,并分别进行比较。结果IV组(8582.02μg/L±4637.42μg/L)、III组(4657.43μg/L±3227.49μg/L)和II组(3449.31μg/L±2297.30μg/L)hs-CRP值明显高于I组(1625.21μg/L±1243.49μg/L)(P<0.05),IV组hs-CRP值明显高于III组和II组(P<0.05),而III组和II组之间差异无显著意义(P>0.05)。在各种病因中,随着颈动脉粥样硬化程度的加重,hs-CRP的水平明显升高(P<0.05),而各病种之间相同颈动脉粥样硬化程度的hs-CRP水平差异无显著意义(P>0.05)。结论炎症反应在颈动脉粥样硬化发生发展中起重要作用,hs-CRP水平可作为颈动脉粥样硬化程度的判断指标之一,且为独立的预测危险因素的指标之一。更多还原

【Abstract】 Objective To study the clinical significance of the levels of serum high sensitive C-reactive protein (hs-CRP) in patients with carotid artery atherosclerosis. Methods The serum hs-CRP was measured by enzyme-labeled polyclonal antibody sandwich method,in the meantime,l45 patients were examined by color Doppler ultrasonography to detect carotid artery atherosclerosis.The patients were divided into 4 groups according to the condition of carotid artery atherosclerosis. Group I(n=31,normal control group),group II(n=48,intimae thickening group),group III(n=27,single plaque group) and group IV(n=39,multiplaque group).The results of serum hs-CRP levels in different groups were compared and all the data were statistically analyzed.Results All the patients were suffered from various degrees of carotid artery atherosclerosis.The serum hs-CRP levels were (8 582.02±4 637.42)μg/L in groupIV,(4 657.43±3 227.49)μg/L in group III,(3 449.31±2 297.30)μg/L in group II,(1 625.2l± 1 243.49 )μg/L in Group I respectively.The serum hs-CRP levels in group IV,group III and group II were significantly higher than those in group I (P<0.05). The serum hs-CRP levels in group IV wre significantly higher than those in group III and group II (P<0.05).There was no significant difference between group III and group II (P>0.05).In the various causes of disease the levels of hs-CRP were closely related to the extent of carotid artery atherosclerosis (P<0.05),while at the same extent of carotid artery atherosclerosis there was no differences in the levels of hs-CRP among various causes of disease (P>0.05).Conclusion The inflammatory reaction can take great role in the development of the carotid atherosclerosis, serum hs-CRP levels have important value in evaluation the carotid atherosclerosis, which is one of the independent risk factors.更多还原