【摘要】 目的对中国汉族人血管紧张素转换酶基因(ACE)内含子16插入(Ⅰ)/缺失(D)多态性与糖尿病视网膜病变(DR)的关联性进行Meta分析。方法以糖尿病视网膜病变组和糖尿病对照组基因型分布的比值比(OR)为统计量,应用REVMAN4.2软件对各研究结果进行一致性检验和数据合并。结果相关文献未发现显著发表偏倚。研究共包括糖尿病视网膜病变组729例,糖尿病对照组903例,数据合并结果DD/(ID+Ⅱ)OR值为1.80,95%可信区间(CI)为1.29～2.50。Ⅱ/(ID+DD)OR值为0.67,95%CI为0.54～0.84。结论汉族人群ACEI/D多态性与DR有关联,糖尿病视网膜病变组DD基因型增多,Ⅱ基因型减少。更多还原

【Abstract】 Objective To study the association between the insertion(Ⅰ)/deletion(D) polymorphism of the angiotensin converting enzyme geneintron 16 (ACE/ID) and diabetic retinopathy (DR) in Chinese population by the means of meta-analysis. Methods Odds ratios of ACE/ID genotype distributions in DR patients against diabetic patients without retinopathy were analysed . The meta-analysis software, REVMAN 4.2,was applied for investigating hetero geneity among individual studies and summarizing effects across studies. Results A total of 729 cases and 903 controls from 13 studies were in cluded. No significant publication bias has been found. The pooled odds ratio (with 95% CI) of DDvs ID + Ⅱ was 1.80 (1.29～2.50),while the pooled odds ration of Ⅱ vs ID+DD was 0.67 (0.54～0.84). Conclusion In Chinese population, ACE I/D polymorphism is associated with DR. The number of DR patients with DD genotype increases while that with Ⅱ genotype decreases.更多还原