【摘要】 目的:探讨原发性高血压(EH)患者血清脂联素(APN)含量的变化及意义。方法:采用酶联免疫法测定41 例EH患者和23例正常健康人的血清APN值。结果:1级EH患者血清中APN水平明显下降(与对照组比较P< 0．01),2级及3级EH患者血清中APN水平进一步下降(与1级比较P<0．05),但2级及3级间差异无显著性(P >0．05)。结论:EH患者脂联素水平降低,提示脂联素与EH的发生、发展过程有关,可作为评价原发性高血压严重 程度的一个新指标。更多还原

【Abstract】 Objective: To investigate the changes of serum adiponectin(APN) content in patient with essential hypertension (EH). Methods: Serum APN contents in 41 EH cases and 23 health cases were measured by ELISA. Results: APN level reduced in early stage of EH (P<0. 01, compared with control group) and continued to reduce in EH grade 2 and 3 (P<0. 05) compared with grade 1, but there was no difference between EH grade 2 and grade 3 (P> 0. 05 ). Conclusion: The result indicates that level of APN significantly decreases in EH patients. APN may be a new marker for severity of essential hypertension.更多还原