【摘要】 目的观察和比较长春瑞滨联合顺氯氨铂(简称NP方案)改良时辰化疗方案和常规化疗方案治疗非小细胞肺癌的近期疗效、临床受益率及不良反应。方法对61例Ⅲ-Ⅳ的非小细胞肺癌患者随机分为时辰化疗组和常规化疗组,治疗两个周期后进行疗效及不良反应的评价。结果时辰化疗组30例,有效率为60%,其中复治21例,有效率57.4%;常规化疗组31例,有效率58.1%,其中复治20例,有效率45.0%;两组比较总有效率无统计学差异,但复治患者相比有效率有显著统计学差异;时辰化疗组不良反应明显低于常规化疗组。结论 NP改良时辰化疗方案同常规化疗方案相比,对复治患者具有明显增高的有效率,并且具有更好的耐受性。更多还原

【Abstract】 OBJECTIVE To evaluate and compare the efficacy and toxicity of time chemotherapy and normal chemotherapy for treatment of non-small-cell lung cancer.METHODS Methods 61 patents with non-small-cell lung cancer were randomized into two groups;one was treated with time chemotherapy regimen,and the others with normal chemotherapy regimen,each case was assessed after2 courses of treatment.RESULTS 30 cases in time chemotherapy group had a response rate of 60%,among them,21 cases retreated had a response rate of 57.4%,31 cases in normal chemotherapy group had a response rate of 58.1%,among them,20 cases retreated had a response rate of 45.0%,between them,there was no significant difference in total curative effects,but for the retreated cases,the response rate in time chemotherapy group was higher than that in normal chemotherapy group,and the toxicity is slighter.CONCLUSION Compared to normal chemotherapy,NP changed time-chemotherapy regimen could clearly increase the response rate espassialy for the retreated cases and can be well tolerated.更多还原