【摘要】 目的观察咪唑安定作为术前用药对行硬膜外阻滞病人应激反应的影响。方法72例拟行硬膜外阻滞的手术患者,ASAⅠ~Ⅱ级,随机分为3组。入手术室前30min肌注不同的术前药。观察病人在不同时刻平均动脉压(MAP)、心率(HR)、脉搏氧饱和度(SpO2)、静脉血糖值(Glu)的变化。同时比较3组病人肌注术前后不同时刻的镇静评分。结果A,B组用药后血压较前显著升高,心率、脉搏氧饱和度无明显改变。C组用药前后血压、心率、脉搏氧饱和度均无明显改变,但血压较A,B组显著降低(P<0.05),心率、脉搏氧饱和度值较A,B组无明显改变。OAA/C评分示C组显著高于A,B组。A组及B组病人入室后各项测定指标均较术前轻度上升,且在硬膜外穿刺后进一步上升(P<0.05),而C组病人变化不大。结论咪唑安定作为术前用药有利于稳定血流动力学,抑制应激反应。更多还原

【Abstract】 Objective To observe the effect of midazolam on stress reaction in patients with epidural anesthesia was used as pre-medication.Methods Seventy-two patients preparing to undergo epidural anesthesia were randomly divided into 3 groups.Each group gives different pre-medication 30 minutes before anesthesia.The changes of MAP,HR,SpO₂,Glu were monitored.The scores of OAA/C also observed.Results In group A and B,MAP increased significantly,but HR and SpO₂ were stable after administering midazolam.In group C,MAP,HR,SpO₂ were all stable before and after administering midazolam.But in group C,the MAP is lower and the HR,SpO₂ were stable comparing with group A and B.The OAA/C scores is increased significantly than group A and B.All the indices in group A and B were slightly higher after entering operation theater and increasing significantly after undergoing epidural anesthesia,but the indices in group C was stable.Conclusion Midazolam as pre-medication has advantage to stabilize hemodynamics and to inhibit stress reaction.更多还原