【摘要】 目的:探讨首发精神分裂症患者远期预后及其影响因素。方法:运用标准化评定工具对146例首发精神分裂症患者进行10年随访及预后评定,对预后有关影响因素作单因素分析和Logest回归多因素分析。结果:首发精神分裂症患者10年随访时总体结局良好者23例(19.2%),一般者34例(28.3%),不良者63例(52.5%)。单因素分析有11项观察指标与预后有关,多因素分析显示远期预后主要影响因素依次为病前职业功能水平、治疗依从性、起病形式和家庭关系。结论:首发精神分裂症患者远期预后受生物、心理、社会多种因素影响,总体结局较差,其中部分影响因素可进行干预。更多还原

【Abstract】 Objective:To study the factors that might affect the prognosis of the first onset schizophrenia.Method:One hundred and forty six first onset schizophrenic patients were enrolled and followed up 10 years.All the data were collected and conducted the single-factor-analysis and Logest analysis.Results:The result showed that 23 patients(19.2%) were markedly improved,34(28.3%) improved,and 63(52.5%) poor.There were 11 factors that might affect the prognosis according to the single-factor-analysis.And there were 4 factors,such as the patients’ occupational status,the compliances,the form of the onset,and their family relationships,that might associate with the prognosis according to the Logest stepwise regression analysis.[WTHZ]Conclusion:In general, the prognosis of the first onset schizophrenia is poor,which is affected by bio-psycho-social factors.Some of these factors could be interfered to improve the prognosis.更多还原