【摘要】 目的观察非药物治疗对血脂异常患者的调脂效果。方法对门诊未接受任何治疗措施的血脂异常患者给予为期6周的非药物治疗干预,包括指导饮食控制、进行健康教育及指导生活方式改善等;干预前后分别检查血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、体质量指数的变化情况。结果45例临床血脂异常患者经6周的非药物治疗后,TC由治疗前(7.05±0.97)mmol/L下降至(5.57±1.40)mmol/L,平均下降21%(P<0.01),LDL-C由(4.28±0.75)mmol/L降至(3.64±1.31)mmol/L,平均下降15%(P<0.01),HDL-C(1.39±0.28)mmol/L升高至(1.54±0.30)mmol/L,平均升高11%(P<0.01);LDL-C的总达标率为66.7%,其中单纯高脂血症患者的达标率为76.9%,而合并高血压和(或)糖尿病患者的达标率为52.6%。结论非药物治疗可以显著降低血TC、LDL-C水平,升高HDL-C水平,是高脂血症患者的首选治疗方法及药物治疗的基础。更多还原

【Abstract】 Objective To observe the regulatory effect of non-pharmaceutical treatment on lipid profile in patients with dyslipidemia.Methods Ambulatory patients with dyslipidemia who had not received any treatment,were intervened with non-pharmaceutical treatment for six weeks,including instructions about diet control,life style improvement and health education and others.The changes in serum total cholesterol(TC),triglycerides, low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C) and body mass index were measured pre-and post-intervention.Results After six weeks of non-pharmaceutical treatment in 45 patients with dyslipidemia,serum TC decreased from((7.05)±(0.97)) mmol/L to((5.57)±(1.40)) mmol/L,in average decreased by 21%(P<(0.01)),LDLC decreased from((4.28)±(0.75)) mmol/L to((3.64)±(1.31)) mmol/L,in average decreased by 15%(P<(0.01)),HDL-C increased from((1.39)±(0.28)) mmol/L to((1.54)±(0.30)) mmol/L,in average increased by 11%(P<(0.01));total rate of target attainment of LDL-C was(66.7)%,among which the patients with simple hyperlipidemia had a rate of target attainment(76.9)%,and the patients complicated with hypertension and/or diabetes had a rate of target attainment(52.6)%.Conclusion Non-pharmaceutical treatment can significantly decrease TC and LDL-C levels and increase the level of HDL-C,and should be the first-line treatment method and the basis of pharmaceutical treatment in patients with hyperlipidemia.更多还原