【摘要】 目的:研究细胞分化诱导剂尿多酸肽(CDA-II)对乳腺癌细胞间粘附分子-1(ICAM-1)表达的的影响。方法:将CDA-II与不同生物学特性的乳腺癌细胞株MCF-7和MDA-MB-231进行体外培养,同时以维甲酸为阳性对照,观察CDA-II对乳腺癌细胞生长曲线、ICAM-1表达及形态学等方面的影响。结果:CDA-II可减缓两株乳腺癌细胞的生长和增殖能力,增加乳腺癌细胞ICAM-1表达。结论:CDA-II可抑制不同生物学特性的两株乳腺癌细胞的生长和增殖能力,诱导乳腺癌细胞ICAM-1表达,为CDA-II治疗乳腺癌提供了实验依据,揭示了其治疗乳腺癌的可能应用前景。更多还原

【Abstract】 Objective:To investigate the effect of CDA-II on the expression of ICAM-1 of breast cancer cells.Methods:The effect of CDA-II on growth curve,expression of ICAM-1 and morphology of breast carcinoma cell lines MCF-7 and MDA-MB-231 were observed in vitro cultures,in comparison with the classical cell differentiation inducer ATRA.MCF-7 and MDA-MB-231 have their different biologic characteristics.Results:CDA-II can reduce the growth speed,proliferation ability and induce ICAM-1 expression of breast cancer cell lines.Conclusion:CDA-II has remarkable effect of anti-cell-proliferation and can increase expression of ICAM-1 on breast cancer cells.Our results provide experimental bases for the treatment of breast carcinoma with CDA-II and also suggest that CDA-II showed good prospects of application for the treatment of breast carcinoma.更多还原