【摘要】 目的:观察和比较静脉注射普罗帕酮、索他洛尔治疗阵发性非瓣膜病快速心房颤动的作用。方法:60例快速房颤发作在0.5-72h的患者,采用随机方式分为两组,分别静脉注射普罗帕酮70-210mg、索他洛尔1.5mg/kg,主要观察快速房颤转复情况及心室率的变化。结果:普罗帕酮、索他洛尔组转复快速房颤的有效率分别为78.1%、39.3%,未转复快速房颠的心室率平均下降幅度分别为5.2%与36%,平均起效时间分别为(46.5±38.2)min,(23.9±11.5)min。结论:在阵发性快速房颤转复过程中静脉注射普罗帕酮的有效率优于索他洛尔,而索他洛尔在减慢快速心室率方面优于普罗帕酮,且索他洛尔平均起效时间短于普罗幅酮。更多还原

【Abstract】 Objective To evaluate effects of propafenone and sotalol in paroxysmal rapid fibrillation in non-rheumatic patients. Methods Sixty patients with rapid atrial fibrillation between 0. 5 and 72 hours were randomly divided into two groups, treated with intravenous propafenone 70-210 mg and sotalol 1. 5 mg/kg respectively. Rhythms and heart rate were monitered. Results The effective rate of cardioversion for rapid atrial fibrillation was significantly highter in propafenone group (78. 1%)than in sotalol group (39. 3%)(P<0. 05). The heart rate in the patients without cardioversion was decreased more in sotalol group(36%) than that in propafenone group (5. 2%)(P<0. 05). While the mean time responding to the bolus was (46. 5 ± 38. 2) and (23. 9 ± 11. 5) minutes. Conclusion Propafenone is more effective than sotalol in reverting rapid atrial fibrillation. However,sotalol is more effective than propafenone in controlling rapid atrial fibrillation.更多还原