【摘要】 使用辛酸亚锡[Sn(Oct)2]作催化剂,D,L-乳酸为原料,合成高分子量聚乳酸。通过粘均分子量、傅立叶红外光谱(FTIR)和核磁共振氢谱(1HNMR)等手段对聚乳酸进行了表征,讨论了聚乳酸分子量的影响因素和聚合条件。将聚乳酸材料植入动物体内,于术后观察其形态、质量及组织学变化。结果表明,当n单体∶n催化剂=5000时,在160℃、1.0×10-7Pa下封管聚合9 h,聚合物粘均分子量可高达43.69×104,具有良好的生物降解性。更多还原

【Abstract】 Polylactic acid（PLA） was synthesized by bulk ring-opening polymerization of high purity lactide prepared by D,L-lactic acid in the presence of catalyst（stannous octoate） under high vacuum.The effect of catalyst、reaction temperature、reaction time and monomer purity on the PLA molecular weight was discussed.The product was characterized by M_v,FTIR,¹HNMR,etc.Biodegradable properties of PLA were investigated by a series of experiments on animals.The results indicated that when polymerization condition was for 9 h,at 160℃,with the molar ratio of monomer to catalyst 5000 and under 1.0×10^-7Pa,the molecular weight could reach 43.69×10⁴ and PLA present good biodegradable properties.更多还原