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大剂量丙种球蛋白治疗Guilain-Barre综合征的疗效观察
Effect of high dose of intravenous immunoglobulin on Guillain-Barre syndrome
【摘要】 目的 :观察静脉滴注大剂量丙种球蛋白 (IVIG)治疗Guilian Barre综合征 (GBS)的疗效。方法 :应用IVIG 0 .4 g·kg-1·d-1连用 5天 ,与同期应用激素冲击治疗的疗效进行比较。结果 :大剂量IVIG治疗GBS临床分级评分和见效时间均优于激素治疗组 (P <0 .0 5和P <0 .0 0 1) ,但两组总有效率差异无显著性 (P >0 .0 5 )。结论 :大剂量IVIG治疗GBS临床分级评分和见效时间均优于激素冲击组
【Abstract】 Objective:To observe the therapeutic effect of high dose of intravenous immunoglobulin (IVIG) in treatment of Guillain-Barre syndrome (GBS).Methods:Eleven patients with GBS were treated with IVIG in a dose of 0.4 g·kg -1·d -1for 5 consecutive days,and the other 16 patients were treated with steroid.The therapeutic effect was compared.Results:The IVIG-treated group was superior to the steroid-treated group in cynical grading scale and time of response(P<0.05 and P<0.001),but there was no significant difference in the total effective rate.Conclusions:Treatment of Guilian-Barre syndrome with high dose of IVIG is superior to that with steroid in clinical grading scale and time of response.
【Key words】 Guillain-Barre syndrome; immunoglobulin; therapeutics;
- 【文献出处】 蚌埠医学院学报 ,Journal of Bengbu Medical College , 编辑部邮箱 ,2005年02期
- 【分类号】R745
- 【下载频次】32