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大剂量丙种球蛋白治疗Guilain-Barre综合征的疗效观察

Effect of high dose of intravenous immunoglobulin on Guillain-Barre syndrome

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【作者】 李袁华周春雷黄辉陈卓邵慧珍赵德明

【Author】 LI Yuan-hua,ZHOU Chun-lei,HUANG Hui,CHEN Zhuo,SHAO Hui-zhen,ZHAO De-ming (Department of Neurology,Huaibei People’s Hospital,Huaibei 235000,China)

【机构】 安徽省淮北市人民医院神经内科安徽省淮北市人民医院神经内科 235000235000235000

【摘要】 目的 :观察静脉滴注大剂量丙种球蛋白 (IVIG)治疗Guilian Barre综合征 (GBS)的疗效。方法 :应用IVIG 0 .4 g·kg-1·d-1连用 5天 ,与同期应用激素冲击治疗的疗效进行比较。结果 :大剂量IVIG治疗GBS临床分级评分和见效时间均优于激素治疗组 (P <0 .0 5和P <0 .0 0 1) ,但两组总有效率差异无显著性 (P >0 .0 5 )。结论 :大剂量IVIG治疗GBS临床分级评分和见效时间均优于激素冲击组

【Abstract】 Objective:To observe the therapeutic effect of high dose of intravenous immunoglobulin (IVIG) in treatment of Guillain-Barre syndrome (GBS).Methods:Eleven patients with GBS were treated with IVIG in a dose of 0.4 g·kg -1·d -1for 5 consecutive days,and the other 16 patients were treated with steroid.The therapeutic effect was compared.Results:The IVIG-treated group was superior to the steroid-treated group in cynical grading scale and time of response(P<0.05 and P<0.001),but there was no significant difference in the total effective rate.Conclusions:Treatment of Guilian-Barre syndrome with high dose of IVIG is superior to that with steroid in clinical grading scale and time of response.

  • 【文献出处】 蚌埠医学院学报 ,Journal of Bengbu Medical College , 编辑部邮箱 ,2005年02期
  • 【分类号】R745
  • 【下载频次】32
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