【摘要】 目的 :分析可溶性Fas及可溶性Fas配体在子宫内膜异位症所致不孕中的可能意义。方法 :采用酶联免疫吸附双抗体夹心法 ,检测 2 0例Ⅰ～Ⅱ期子宫内膜异位症不孕患者血清及腹腔液中可溶性Fas及可溶性Fas配体溶液 ,并与 14例慢性盆腔炎致不孕者和 16例健康生育者比较。结果 :子宫内膜异位症不孕患者血清和腹腔液内溶性Fas配体浓度 (分别为 175 .0 9± 80 .5 0pg/ml和 2 84 .5 0± 15 2 .38pg/ml) ,显著高于健康生育对照 (血清 16 .13± 11.75 pg/ml;腹腔液 8.84± 2 .31pg/ml)及慢性盆腔炎致不孕者 (血清 88.4 7± 4 3.5 5 pg/ml;腹腔液 17.30± 9.6 2 pg/ml)。其可溶性Fas抗原水平 (血清 82 8.6 0± 4 2 9.6 5Ppg/ml;腹腔液 349.6± 2 88.89pg/ml)与盆腔炎组 (血清 86 8.75± 5 70 .4 8pg/ml;腹腔液 181.76± 15 7.78pg/ml)及健康生育组 (血清 82 2 .2 6±12 9.12 pg/ml;腹腔液 318.4 2± 14 5 .16 pg/ml)相比 ,均无统计学显著差别。 结论 :可溶性Fas配体与子宫内膜异位症所致不孕具有显著相关性 ,可能在其盆腔局部微环境改变致不孕中具重要意义。更多还原

【Abstract】 Objective:To investigate the relationship between the level of soluble Fas antigen(sfas) and soluble Fas ligand(sFasL) and endometriosis associated infertility.Methods:The sfas and sFasL level in sera and peritoneal fluid of infertile women with endometriosis were assessed with enzyme-linked immunosorbent assay,and were compared with those of 14 infertile women resulting from chronic pelvic infectious disease and 16 fertile controls.Results:The sFasL levels(175.09±80.50pg/ml in sera and 284.50±152.38pg/ml in peritoneal fluid) were significantly higher in infertile patients with endometriosis than those of infertile controls(88.47±43.55pg/ml in sera and 17.30±9.62pg/ml in peritoneal fluid) and fertile controls(16.13±11.75pg/ml in sera and 8.84±2.31pg/ml in peritoneal fluid).Compared with the levels of sfas in infertile women resulting from pelvic infectious disease(868.75±570.48pg/ml in sera and 181.76±157.78pg/ml in peritoneal fluid) and fertile control group(822.26±129.12pg/ml in sera and 318.42±145.16pg/ml in peritoneal fluid),the values of sfas in infertile patients with endometriosis(828.60±429.65pg/ml in sera and 349.6±288.89pg/ml in peritoneal fluid) have no significant difference.Conclusion:Endometriosis-related infertility has great association with the level of sFasL,and sFasL may play a key role in the local homeostatic regulation in endometriosis and in turn result in the development of its associated infertility.更多还原