【摘要】 幽门螺杆菌(HP)感染与CSG→CAG→IM→DYS→GC的病理变化过程密切相关,且HP感染引起的胃部病变过程与人体免疫关系密切.HP致病过程与胃黏膜病变基因表达和细胞分子学行为的改变有关.而Se也与人体免疫关系密切,且Se与胃黏膜基因表达和细胞分子生物学行为的变化也关系密切.最近,有资料显示胃窦炎患者胃窦组织中Se与HP感染有关.在胃癌前病变胃黏膜损害的患者中Se水平相对降低,并有资料显示在HP感染的CSG→CAG→IM→DYS→GC过程中Se水平是有明显改变的.更多还原

【Abstract】 H Pylori infection correlates highly with the process of alteration in pathology from CSG to GC (CSG→CAG→IM→DYS→GC), it is related to the human’s immune system, and it is connected with the expression of multiple genes and behavior of cellular biology in gastric lesions, too. Selenium is correlated with not only the human’s immune system but also the expression of multiple genes and behavior of celuar biology in gastric alteration. The results showed that antral tissue selenium levels is related to H. Pylori infection in chronic antral gastritis and lower mucosal selenium level in patients with precancerous gastric lesions(CAG IM), another data suggests alteration of selenium is significant in the process of alteration of pathology from CSG to GC with H. Pylori infection.更多还原