【摘要】 目的探讨2型糖尿病外周神经病变和血清离子钙(Ca2+)水平的关系。方法应用离子电极法测定了45例2型糖尿病外周神经病变患者和56例2型糖尿病无外周神经病变患者的血清Ca2+水平,并与31名健康对照者作比较。结果2型糖尿病外周神经病变组血清Ca2+水平为穴1.064±0.055雪mmol蛐L,明显低于糖尿病无外周神经病变组的穴1.140±0.039雪mmol蛐L(P<0.05)和对照组的穴1.160±0.046雪mmol蛐L(P<0.05);2型糖尿病无外周神经病变组与正常对照组之间的差别则没有显著性意义(P>0.05)。血清Ca2+水平与年龄、收缩压及甲状旁腺激素水平呈负相关(P<0.05)。结论2型糖尿病外周神经病变患者血清Ca2+水平下降,提示Ca2+代谢紊乱可能参与了2型糖尿病外周神经病变的发病过程。更多还原

【Abstract】 Objective To investigate the relationship between serum calcium ion,Ca2+, levels and diabetic peripheral neuropathy. Methods Serum Ca2+ levels were determined by ion-specific electrode in 101 type 2 diabetic patients (45 with peripheral neuropathy and 56 without neuropathy)and 31 healthy subjects. Results The diabetic patients with peripheral neuropathy had significantly lower levels of serum Ca2+ (1.064±0.055mmol,L)compared with those in diabetic patients without peripheral neuropathy (1.140±0.039mmol,L,P<0.05)and to controls (1.160±0.046mmol,L,P<0.05,. No significant difference of serum Ca2+ was found between the diabetic patients without peripheral neuropathy and control subjects. Conclusion There are disturbances in the homeostasis of cytosolic calcium concentration in diabetic neuropathy.更多还原