【摘要】 用LC-MS和HPLC法以对照品对照,确定吡喹酮合成过程中产生的主要杂质是(1,11b)-位不饱和的吡喹酮,利用催化氢化法可把含该杂质过量的吡喹酮粗品转化为合格品。更多还原

【Abstract】 The structure of the main related compound in praziquantel was determined to be 2-(cyclohexylcarbonyl)2,3,6,7-tetrahydro-4H-pyrazino[2,1-a]-iso-quinolin-4-one by LC-MS and HPLC with praziquantel reference. The relatedcompound could be transformed to praziquantel by catalytic hydrogenation.更多还原