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禽流感(H9亚型)油乳剂灭活疫苗的血凝抑制(HI)抗体动态变化的研究

The study of antibody developping changes of inactivated oil-emulsion against H9 subtype Avian influenza Virus

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【作者】 陈一兵刘岳龙刘雷解增俊印继华丛华沈海蜂

【Author】 Chen Yibing,Liu Yuelong,Liu Lei,Xie Zengjun,Yin Jihua,Cong Hua,Shen Haifeng (College of Veterinary Medicine,Yangzhou University, Jiangsu,Yangzhou 225009,China)

【机构】 扬州大学兽医学院扬大生物制品研究开发中心扬州大学兽医学院扬大生物制品研究开发中心 江苏扬州225009江苏扬州225009江苏扬州225009

【摘要】 从市场上随机购得不同厂家各两批次的商品化禽流感(H9)油乳剂灭活疫苗,按瓶签说明免疫禽流感母源抗体为阴性的蛋鸡。当疫苗抗体下降至5log2左右时部分鸡再二免,并做田间试验。结果表明,免疫1周出现血清抗体,并逐日上升,3周达高峰。首次免疫8周后抗体下降至5log2左右,二次免疫15周后抗体下降至5log2左右。这四批疫苗的免疫原性较高,安全可靠,两次免疫保护期可保护至开产后。

【Abstract】 Two different batches of commercial inactivated oil-emulsion vaccines for avian influenza virus were randomly bought from two different manufacturers respectively.Chicken with negative maternal antibody against AIV were immuned follow the instruction on the bottle label.The results of immunity experiment shows that the antibody could be produced 1 week after immunity and reached its peaks within 3 weeks.The antibody declined to 5log2 8 weeks after the first immunity and 15 weeks after the secondly immunity.Above all,these vaccines were safe and effect of immunity.

【关键词】 禽流感(AI)免疫血凝抑制(HI)效价
【Key words】 Avian influenza(AI)immunityantibody(HI)
  • 【文献出处】 中国家禽 ,China Poultry , 编辑部邮箱 ,2004年22期
  • 【分类号】S852.4
  • 【被引频次】7
  • 【下载频次】185
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