【摘要】 目的　探讨带蒂大网膜包肾术 (POT)对肾小球硬化大鼠肾皮质IV型胶原基因表达的影响。方法采用单侧肾切除加二次注射阿霉素制备肾小球硬化大鼠模型 ,观察带蒂大网膜包肾术对肾小球硬化大鼠肾皮质IV型胶原基因表达的影响。结果　带蒂大网膜包肾术使肾小球硬化大鼠肾皮质IV型胶原基因表达明显上调 ,肾小球硬化减轻。结论　带蒂大网膜包肾术下调肾小球硬化大鼠肾皮质IV型胶原基因表达 ,延缓肾小球硬化更多还原

【Abstract】 Objective To investigate the effect of pedicled omental transposition on type IV collagen mRNA in glomerulosclerosis rats. Methods Three groups of 24 uistar rats were studied: 9 as normal control, 6 as glomerulosclerosis group induced by unilateral nephrectomy and injection of adriamycin, and 9 glomerulosclerosis rats treated with pedicled omental transposition surgery as pedicted omental transposition group.Results Pedicled omental transposition group could not only decrease the accumulation of extracellular matrix(P<0.05), but also the expression of type IV collagen mRNA (P<0.05). Conclusion Pedicled omental transposition may decrease the accumulation of extracellular matrix and attenuate glomerulosclerosis by down-regulating type IV collagen mRNA expression.更多还原