【摘要】 目的 :观察中药复方糖末宁对糖尿病大鼠神经传导速度、红细胞山梨醇 (RBC S)含量等指标的影响 ,探讨其防治糖尿病周围神经病变的机制。方法 :采用链脲佐菌素糖尿病大鼠模型 ,给予糖末宁灌胃 (2 .95、5 .90、11.80g·kg-1,i.g)连续3周 ,以甲钴胺作为阳性对照组 ,并设正常对照组及模型对照组 ,观察治疗前后对糖尿病大鼠神经传导速度、RBC S含量的影响。结果 :糖末宁治疗后 ,与模型组和治疗前相比 ,中剂量组和大剂量组对尾神经传导速度减慢有显著增加作用 (P<0 .0 5 ) ;治疗后 ,糖末宁及甲钴胺组RBC S含量明显下降 (P <0 .0 1) ,中剂量组RBC S含量低于模型组 (P <0 .0 5 )。结论 :糖末宁对糖尿病神经病变的治疗作用 ,可能与纠正多元醇代谢异常作用有关。更多还原

【Abstract】 AIM: To investigate the effects of Tangmoning (TMN) Granule on nerve conduction velocity, red blood cell sorbitol (RBC S) level in diabetic rats and probe the mechanism of prevention and treatment of diabetic peripheral neuropathy. METHODS: The model of diabetic rat was induced by strepotozotocin. The animals were randomly divided into six groups:TMN minimal dose group, TMN mild moderate dose group, TMN maximal dose group, methycobal group, model group and normal control group. All TMN groups were treated with TMN Granule through tube feeding (2.95 g/kg、5.90g/kg、11.80g/kg). Methycobal group was treated with methycobal tablets through tube feeding (0.14mg/kg). The duration of treatment was 3 weeks. The caudal nerve conduction velocity, RBC S content were investigated before and after treatment. RESULTS: It showed that TMN Granule could increase the caudal nerve conduction velocity significantly in the maximal dose group and the mild moderate dose gorup ( P <0.05), and decrease RBC S level( P <0.05) in the mild moderate dose group, compared with the model group. CONCLUSION: It suggests that Tangmoning Granule should play a role in increasing nerve conduction velocity, the machanism may be relative to correcting for anomaly of polyol metabolism.更多还原