Effect of Cerium on Expression and Activity of MMP-9 from Human Carcinoma of Bladder Cell Line

【Abstract】 The effects of Ce⁴⁺ on cell survival, expression and activity of matrix metalloproteinase-9 （MMP-9） with MTT colorimetry and gelatin zymography assays in human bladder carcinoma cell line was studied. The results indicate that the lower concentration of Ce⁴⁺ (0.01 mmol·L^-1) has no influence on cell growth, but inhibits extremely expression of MMP-9 and increases its activity, whereas the higher concentration of Ce⁴⁺ (1.0 mmol·L^-1) can inhibit all of them. The results raise the possibility that Ce⁴⁺ may have beneficial effects in attenuating invasion and metastasis of malignant tumors.更多还原