【摘要】 目的分析利巴韦林治疗SARS患者与心率减慢的关系,为临床合理用药提供参考。方法采用药物流行病学病例对照研究的方法,回顾分析我院181例SARS患者使用利巴韦林治疗与心率减慢的关系。结果本文研究发现,使用利巴韦林治疗SARS患者有减慢心率的作用,且多发生在用药后0～3d,并可能与剂量有关;其发生心率减慢/心动过缓的例数与对照组比较有显著性差异(P<0.05),引起心率减慢的危险性是对照组的4.1倍(1.59～10.55)。结论利巴韦林治疗SARS患者有致心率减慢的不良反应。更多还原

【Abstract】 Objective: To investigate whether bradycardia is related with ribavirin treatment in SARS patients. Methods: 181 cases with SARS were retrospectively enrolled and divided into two groups in this case-control study, that is, ribavirin group (ribavirin and basic therapy) and control group (basic therapy only). Results: Compared with control group, ribavirin therapy decreased the SARS patients’ heart rate (p< 0.05) at 0-3 days and OR was 4.1(1.59-10.55). Conclusion: When given by intravenous infusion, ribavirin caused a dose-related bradycardia in SARS patients.更多还原