【摘要】 [目的 ]研究抗癫痫新药Rufinamide的合成工艺 .[方法 ]合成方法是以 2 ,6 二氟苯甲酸为起始原料 ,经酯化、NaBH4还原及卤化得取代 2 ,6 二氟氯苄 ,再与迭氮钠反应得 2 ,6 二氟苄基迭氮 ,最后再与丙炔酸乙酯环合及酰氨化得Rufinamide.[结果 ]所合成的目标化合物经核磁共振氢谱、元素分析和质谱确认了化学结构 .更多还原

【Abstract】 OBJECTIVE?To study the synthesis process of the Rufinamide as a new antiepileptic medicine.?METHODS?By us ing 2,6-difluorobenzoic acid as the starting material, 2,6-difluorobenzyl chlo ride was prepared via esterification, NaBH 4 reduction and halogenation, which subsequently reacted with sodium azide to give 2,6-difluorobenzyl azide, th en t he Rufinamide was obtained via cyclizing with ethyl propiolate and amidating.? RESULTS?The structure of the synthesized compound is determined by 1 H-NMR, IR and MS.更多还原