【摘要】 目的:观察骨疏康治疗绝经后妇女膝骨关节炎的疗效。方法:参照美国“风湿病学”(1995年)的骨关节炎诊断标准,选择绝经后妇女膝骨关节炎患者60例,口服骨疏康颗粒(康辰医药发展有限公司东港制药厂生产)。2次/d,10g/次,连服1个月。服药前后进行膝关节功能评定,同时进行血清雌二醇含量测定,进行自身配对t检验法。结果:治疗前后膝关节功能平均分值分别为51.57和72.63分,差异有非常显著性意义(P<0.01),血清雌二醇治疗前后平均值分别为56.78和102.67(pmol/L),差异有显著性意义(P<0.05)。结论:骨疏康对绝经后妇女膝骨关节炎具有减轻疼痛,调整骨代谢及改善骨生物力学性能,提高骨强度,从而明显改善膝关节的功能障碍,提高绝经后妇女生活质量。更多还原

【Abstract】 AIM:To study the therapeutic effect of gushukang on knee osteoarthritis of postmenopausal women. METHODS:The experiment was conducted according to the diagnostic criteria for osteoarthritis based on rheumatology of America.Sixty postmenopausal women with knee osteoarthritis were treated with gushukang(produced by Donggang Pharmaceutical Factory,Healthstar Medical Development Co.,Ltd.) 10 g twice per day for 1 month.The knee function was assessed,and the serum estradiol level was measured before and after treatment for the auto pairing t test. RESULTS:The knee functional assessment was 72.63 after treatment,significantly different from that before treatment(51.57)(P< 0.01).The serum estradiol level was 102.67 pmol/L after treatment,significantly different from that before treatment(56.78 pmol/L)(P< 0.05). CONCLUSION:Gushukang can relieve pain,balance bone metabolism,improve the characteristics of bone biomechanics,and enhance bone intensity,thus the function disabilities of knee joint,and quality of life of postmenopausal women with knee osteoarthritis are improved.更多还原