【摘要】 目的 :为了解天津地区下呼吸道不动杆菌感染的临床特点和对抗生素耐药情况。方法 :采用回顾性分析的方法 ,对天津地区10家医院2000年1月～2002年9月底呼吸科287例住院患者下呼吸道不动杆菌感染的临床和对抗生素耐药性进行了调查。结果 :天津地区3年来下呼吸道不动杆菌感染的特点为 :高龄老年多见72.2% ,有基础疾病者多见75.96 % ,曾使用抗生素者占59.23 % ,使用糖皮质激素4.53%。不动杆菌属药物敏感率在79.00 %以上的抗生素依次为亚胺培南、替卡西林、阿米卡星、头孢哌酮/舒巴坦、妥布霉素及左氧氟沙星等。对亚胺培南的耐药率最低5.8% ,其次为替卡西林9.2 %、头孢哌酮/舒巴坦10.0 %及阿米卡星11.4 %。对头孢噻吩、头孢唑啉、头孢呋辛、氨苄西林及氨曲南等抗生素的耐药率较高。结论 :下呼吸道不动杆菌感染的临床表现无特殊性 ,治疗应根据细菌药物敏感选用抗生素更多还原

【Abstract】 Objective:To investigate the clinical manifestations and the antibiotic resistance of Acinetobacter from the lower respiratory tract infection in Tianjin.Methods:The clinical data and the antibiotic resistance of the lower respiratory tract infection caused by Acinetobacter of287cases in respiratory department of10hosˉpital in Tianjin were reviewed from Jan.2000to Oct.2002.Results:The feature:Most of cases were the elder patients(72.2%),75.96%of cases had underling disease,59.23%were given broad-spectrum antibiotics,and4.53%were given glucocorticoid.Antibiotic sensitivity test in vitro showed that drugs with sensitive rate above79.00%included imipenem,ticarcillin,amikacin,cefoperazone/salbactam,tobramycin and levofloxacin.The resistant rate of Acinetobacter to imipenem was the lowest(5.8%),followed by ticarcillin(9.2%),cefoperaˉzone/salbactam(10.0%),amikacin(11.4%).The resistant rate of Acinetobacter was high to drugs such as cephalothin,cefazolin,cefuroxime,ampicillin and aztreouam.Conclusions:Clinical manifestations of the lower respiratory tract infection caused by Acinetobacter were no specificity,so the antibiotic uses should be selected according to the results of susceptibility test.更多还原