【摘要】 研究药物辅助扩张皮瓣的本构关系以及对其生物力学特性进行数学描述 ,探讨其临床意义 ,为应用和推广药物辅助组织扩张技术提供理论基础。以小型猪为实验动物 ,分为用药扩张组和常规扩张组 ,用药扩张组在组织扩张过程中外用罂粟碱霜 ,两组均在扩张过程中取皮瓣试件 ,进行应力 -应变测定 ,并拟合出试件的应力 -应变理论曲线和本构方程。结果表明 ,药物辅助扩张皮瓣和常规扩张皮瓣的本构关系均可用指数函数形式的本构方程和应力 -应变理论曲线描述 ,药物辅助扩张皮瓣的粘弹性较常规扩张皮瓣有提高和增强的趋势。表明移植时扩张皮瓣 ,选择药物辅助扩张皮瓣可减缓组织张力的增加 ,有利于创面愈合和扩大修复范围更多还原

【Abstract】 In order to disscuss the clinical signification on expanding skin flap with papaverine cream and to offer a theory for its application and popularization ,the study was to evaluate the constitutive relation and to find an expression for its biomechanical properties by mathematical methods. Small porines were were divided into two groups: medication expansion group, conventional expansion group. Papaverine cream was applied externally in medication expansion group during skin flap expansion. The stress-strain was measured in each group during skin flap expansion and was fitted with theoretical curves and constitutive equations, and the mathematic model was obtained. An expression for the constitutive relation of expanding skin flap was found by the exponential function type of constitutive equation and that of theoretical curve. The viscoelasticity of medication expansion skin flap trended to enhancement as compared with that of conventional expansion skin flap. The results indicates that medication expansion skin flap can reduce the increase on tissue tensile force in some degree and benefit wound concrescence and expand repair area when expanding skin flap transplanted.更多还原