【摘要】 目的观察普贝生促宫颈成熟和引产的临床效果及其安全性。方法将100例无阴道分娩禁忌、单胎、胎位正常的足月待产孕妇分为2组。试验组:将普贝生一枚放置于阴道后穹窿,若无不良反应,12h后取出。对照组:将同外形的安慰剂一枚放置于阴道后穹窿,12h后取出。两组用药前及用药后6、12h分别进行宫颈Bishop评分。结果①用药后6、12h宫颈评分,普贝生组分别为(3.65±1.16)、(6.58±1.93)分,明显高于对照组(2.48±1.15)和(2.78±1.54)分(P<0.001)。②12h后普贝生组宫颈成熟率及显效和有效率均明显高于对照组。普贝生组12、24h内临产明显高于对照组。③两组新生儿结局无明显差异。有2例发生子宫过度刺激,均未导致不良后果。结论普贝生是一种有效和安全的促宫颈成熟和引产药物,对母儿无明显不良影响。更多还原

【Abstract】 Objective To observe the clinical effects and safety of pepidil on maturing cervix and parturifacient action. Methods 100 single term pregnant wom en with proper fetal position without any vaginal delivery taboo were divided in to two groups. One was the test group, in which one piece of pepidil was put int o the vaginal posterior fornix for 12 hours. Another was the control group, in w hich the placebo with the same shape was used instead. The cervixes were evaluat ed with Bishops method before this management and 6 and 12 hours after treatme nt. Results (1) The Bishops evaluations of cervixes 6 and 12 hours after treat ment in the pepidil group were 3.65±1.16 and 6.58±1.93 respectively. It was ob viously higher than those in the control group, which were 2.48±1.15 and 2.78± 1.54(P< 0.001). (2) The pepidil group had much better efficiency and effects on cervix mature 12 hours after treatment compared with the control group, and had higher incidences of turn in labor in 12 or 24 hours.(3) The neonatal outcomes h ad no significant differences between two groups. There were 2 case showed hyper -stimulation of uterine, however, there were no adverse effect. Conclusions Pep idil is a kind of effective and safe drug for cervix maturing and patrurifacient and has no adverse effect to the mothers and babies.更多还原