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中华眼镜蛇毒组份Ⅲ的碘化标记物制备及质量鉴定

Preparation and Quality Identification of Iodide of Fraction III Isolated from Naja naja atra Venom

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【Author】 HOU Li-qiang~1,QIANG Yong-gang~2,ZHAO Lu-ning~1,LIN Zhen-tao~1,LIAO Yong-hua~2,GUAN Jin-xia~1(1.Guangzhou Research Institute of Snake Venom, Guangzhou 510182,China;2.Department of Nuclear Medicine,Guangzhou Medical College, Guangzhou 510182,China)

【机构】广州医学院蛇毒研究所；广州医学院实验核医学教研室；广州医学院蛇毒研究所广东广州　510182；广东广州　510182；广东广州　510182；广东广州　510182；

【摘要】目的:研究对眼镜蛇毒(Najanajaatravenom)组份III进行125I放射性标记的方法及其质量评价.方法:用氯胺-T法碘化标记眼镜蛇毒组份III.结果:用氯胺-T法按125I标记组份III,标记物放化纯为98.38%,比活度为0.945mCi/mg,RF值为0.76,每个组份III分子上带0.56个125I原子,与非标记组份III有相同的生物学活性和理化性质.结论:所标记的眼镜蛇毒组份III符合放射结合分析的要求.更多还原

【Abstract】 To study the methods with which Fraction III isolated from Naja naja atra venom was （）^125I-labelled and quality evaluation. Methods:Fraction III from Naja naja atra venom was labelled with （）^125I by chloramine-T method. Results:The marker’s radiochemical purification was 98.38%, the ratio of activity was 0.945mCi/mg,and the RF was 0.76. Each molecule of Fraction III carried 0.56 （）^125I atom, and their biological activity and physiochemical property equalled that of the unlabelled Fraction III. Conclusion:The （）^125I- labelled Fraction III isolated from Naja naja atra venom was fitted to the demand of radiation combinant analyse.更多还原

【关键词】组份III；眼镜蛇毒； 125I放射标记；
【Key words】 Fraction III； Naja naja atra venom； ()¹²⁵I-labelled；

【文献出处】内蒙古民族大学学报(自然科学版) ,Journal of Inner Mongolia University for Nationalities(Natural Sciences,Quarterly) , 编辑部邮箱 ,2004年02期
【分类号】R943
【下载频次】27

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