【摘要】 目的 :探讨特发性全面强直阵挛发作 (generalizedtonicclonicseizure ,GTCS)癫患者发作间期局部脑血流 (rCBF)特征。方法 :用单光子发射计算机断层显像 ( 99Tcm ECD SPECT)技术对 2 0例新发病的特发性GTCS患者发作间期rCBF特征进行观察 ,以兴趣区(ROI)法作半定量分析。结果 :2 0例新发病的特发性GTCS患者发作间期rCBF异常率为 3 0 % ( 6例 ) ,主要表现为一侧丘脑区或基底节区的放射性稀疏。结论 :新发病的特发性GTCS患者的rCBF存在两种特征 :①正常的CBF ;②一侧丘脑区CBF降低 ,CBF降低的丘脑区可能为亚临床病灶更多还原

【Abstract】 Aim:To study the difference of regional cerebral blood flow (rCBF) in new-onset patients of idiopathic generalized tonic clonic seizure (GTCS).Methods:Interictal rCBF measurements using 99Tc m-ethyl cysteinates dimer (ECD) SPECT was performed on 20 new-onset idiopathic GTCS patients.The rCBF distribution was semi-quantitatively analyzed by regions of interest (ROIs).Results:The abnormal rate of hypoperfusion rCBF in new-onset patients with idiopathic GTCS was higher than that of age-matched healthy persons significantly (P<0.05).ROI analysis showed that 30% of new-onset patients with idiopathic GTCS had interictal hypoperfusion rCBF in basal ganglia or thalamus.Conclusion:Our results demonstrated that there are two kinds of condition of the interictal hypoperfusion rCBF in the new-onset idiopathic GTCS:one is normal;the other is the hypoperfusion rCBF of thalamus.更多还原