【摘要】 目的 :观察云南松籽油 (YSY)对糖尿病 (DM )小鼠的血糖调节作用 .方法 :选择采自云南楚雄市郊云南松种子 ,经低温压榨、萃取制成精油 ,观察对四氧嘧啶诱导的糖尿病小鼠的降血糖效果及对正常小鼠血糖的作用 .结果 :以YSY2、 4、 6 g/ (kg d)三个剂量连续igDM小鼠 30d ,YSY 6 g/ (kg·d)剂量组能显著降低DM小鼠血糖水平 (P <0 0 5 ) ,4 g/ (kg·d)剂量组血糖虽有所降低 ,但无显著差异 (P >0 0 5 ) ,2g/ (kg·d)剂量组未呈现降血糖作用 (P >0 0 5 ) ,YSY各剂量组间降血糖作用呈现一定剂量 -效应关系 .以YSY 6 g/ (kg·d)剂量连续ig正常小鼠 30d ,未发现有降低正常小鼠血糖作用 .结论 :云南松籽油具有降低糖尿病小鼠血糖的作用 ,对正常小鼠血糖无不良影响 ,其降血糖机理有待深入研究 .更多还原

【Abstract】 Objective:To study the effects of YSY from Chuxiong on regulating blo od glucose in diabetic mice. Methods:The anti-hyperglycemic effect of YSY was i nvestigated in normal mice and diabetic mice induced by alloxan. Results:After hypoglycemic mice were fed YSY 2,4,6?g/(kg bw·d) for 30?days, the glucose le vel did not change significantly in both 2?g/(kg·bw·d) group and 4?g/(kg·bw ·d) group(P>0 05),but sercum glucose of ig. 6?g/(kg·bw· d) group was reduced obviously compared with the control(P<0 05). Con clusion:YSY may decrease blood glucose in diabetic mice and not change serum gl ucose level in normal mice.[更多还原