【摘要】 介绍了一种新的177Lum分离纯化方法:堆照天然Lu2O3靶,经过长时间冷却后,配制成0.1mol/L的HCl溶液并注入NH+4型阳离子交换柱,用0.12mol/Lα 羟基异丁酸洗脱177Lum及其他放射性核素,将含有177Lum的洗脱液通过H+型阳离子交换柱,用0.1mol/LHCl溶液除去α 羟基异丁酸,又用6mol/L的HCl洗脱、蒸干后得到177Lum的0.1mol/LHCl溶液。最后得到177Lum的放射性活度为18.17MBq,Lu2O3比活度为0.624MBq/mg,放射性纯度大于99%,产率为97%。用得到的177Lum对EDTMP进行标记,建立了测定177Lum EDTMP标记率的快速展开体系。当ρ(EDTMP)>0.15mg/mL,ρ(Lu2O3)=0.047mg/mL,pH=5～11,在室温下反应5min时,177Lum EDTMP的标记率大于97%。表明177Lum EDTMP可用于潜在骨肿瘤治疗剂177Lu EDTMP的进一步研究。更多还原

【Abstract】 The new separation and purification method for¹⁷⁷Lu^m is investigated: the solution of 30 mg natural Lu₂O₃ target irradiated with thermal neutron for 26 d and decayed for 11 months is passed through a NH⁺₄ type cation exchange column,¹⁷⁷Lu^m and other radionuclides are separated with 0.12 mol/L α-hydroxyisobytyric acid eluent. The¹⁷⁷Lu^m is purified from the 0.12 mol/L α-hydroxyisobytyric acid by elution 0.1 mol/L HCl from a H⁺ type cation exchange column. The labeling of EDTMP with¹⁷⁷Lu^m is obtained. The results show radioactivity of purified¹⁷⁷Lu^m is 18.17 MBq, special （activity） 0.624 MBq/mg Lu₂O₃, radioactive purity over 99%, the yield is 97%. The fast paper chromatography of¹⁷⁷Lu^m-EDTMP is established, the labeling efficiency of¹⁷⁷Lu^m-EDTMP is more than 97% with the optimized labeling condition: ρ（EDTMP）>0.15 mg/mL, ρ（Lu₂O₃）=0.047 mg/mL, pH=5～10, the room temperature, 5 min.¹⁷⁷Lu^m-EDTMP can be used in the further study of¹⁷⁷Lu^m-（EDTMP）, which a potential therapeutic agent for bone metastases.更多还原