【摘要】 脆性X智力低下蛋白(fragile mental retardation protein,FMRP)的表达缺失引起一种遗传性智力低下疾病——脆性X综合征。此蛋白是一种RNA结合蛋白,与mRNAs转运及多聚核糖体和突触的功能有关。因此,要了解脆性X综合征的发病机理,关键在于找到与FMRP蛋白结合的mRNAs,以及FMRP与这些靶mRNAs的结合对它们的代谢和翻译有何影响。更多还原

【Abstract】 Loss of fragile mental retardation protein (FMRP) causes the fragile X mental retardation syndrome. FMRP is an RNA-binding protein associated with the transport of mRNAs and the functions of polysomes and synapses. The key to the understanding of the molecular mechanism of Fragile X snydrome is to identify the interactions between FMRP and mRNAs, and their influence on the metabolism and translation of the target mRNAs.更多还原