【摘要】 在自制的涂敷型纤维素三 (3,5 二甲基苯基氨基甲酸酯 ) (CDMPC)和Pirkle型 (S ,S) Whelk O1两种手性柱上 ,对 6种酸性化合物 (西替立嗪、外消旋萘普生、托品酸、布洛芬、酮洛芬以及 2 ,2 二苯环丙烷羧酸 )进行了对映体分离。考察了在流动相正己烷中 ,不同的醇类添加剂、酸性添加剂对手性分离的影响 ,研究了溶质的体积大小及空间立体结构因素对手性分离的影响 ,并初步探讨了手性识别机理更多还原

【Abstract】 Cellulose and cellulose derivatives are biopolymers which are often used as stationary phases for the separation of enantiomers. Describing the mechanism of such separations is a difficult task due to the complexity of these stationary phases. In this paper, the separation of six acidic compounds (cetirizine, naproxen, tropic acid, ibuprofen, ketoprofen and 2,2-biphenyl-cyclopropanecarboxylic acid) was studied on two chiral columns-trtis(3,5-dimethylpheny carbmate) (CDMPC) and (S,S)-Whelk-O1 chiral columns. The influence of the structures of the analytes on the chiral separation was investigated. The mobile phase composition including the concentration and type of the alcohol modifier and the acidic additive in hexane was varied, and the influence on the retention factor(k′) for each enantiomer, the separation factor(α) and the resolution (R) was studied. Then the two different chiral recognition mechanism were discussed and compared.更多还原