【摘要】 目的 :比较 10 g/L氯普鲁卡因与 1.2 5g/L罗哌卡因用于硬膜外自控分娩镇痛的效果 .方法 :ASAⅠ～Ⅱ级的初产妇 4 8例分为氯普鲁卡因和罗哌卡因两组 (n =2 4 ) ,在宫口开至 2～ 3cm时给予镇痛液配方为 10 g/L氯普鲁卡因 +0 .0 3g/L芬太尼或 1.2 5g/L罗哌卡因 +0 .0 3g/L芬太尼的硬膜外自控分娩镇痛 ,至第二产程开始时停止 .观察并记录镇痛前、给予硬膜外负荷量后 5min ,30min ,宫口开全时的疼痛评分 (VAS)和运动神经阻滞评分 (MBS)以及各产程时间 ,新生儿出生后 1min ,5min的Apgar评分 .结果 :氯普鲁卡因组的疼痛评分较罗哌卡因组在给负荷量后 5min低 (P <0 .0 1) ,其余各时间点的疼痛评分均无差异 .两组的运动神经阻滞评分、产程时间、新生儿出生后 1min ,5min的Apgar评分在各时间点均无统计学意义 .结论 :氯普鲁卡因 10g/L与1.2 5 g/L罗哌卡因的硬膜外分娩镇痛效果相当 .更多还原

【Abstract】 AIM: To compare the effects of epidural 10 g/L chloroprocaine and 1.25 g/L ropivacaine by patient-controlled epidural analgesia (PCEA) in labour. METHODS: Forty-eight ASA I or II first time lying-in women requesting epidural analgesia in early labor were allocated to receive either 10 g/L chloroprocaine with 0.03 g/L fentanyl or 1.25 g/L ropivacaine with 0.03 g/L fentanyl via a patient-controlled analgesia pump. The pump was stopped at the beginning of the second stage of labor. Visual Analgesia Scores (VAS) and Modified Bromage Score (MBS) were estimated and recorded at four time points: Before analgesia, 5 min after epidural loading dose, 30 min after epidural loading dose, and beginning of the second stage of labor. Duration of labor and Apgar scores at 1min and 5 min after parturition were also compared. RESULTS: There was a significant difference in VAS at 5min after epidural loading dose between the two groups and no difference was observed at other time points. MBS, duration of labor, and Apgar scores were similar in the two groups. CONCLUSION: A 10 g/L chloroprocaine and 1.25 g/L ropivacaine are clinically of similar effects in labor analgesia.更多还原