【摘要】 目的　观察IFN -浕联合吲哚美辛在慢性乙型肝炎患者治疗中的效果?椒ā?87例符合条件的慢性乙肝患者随机分为两组 ,分别给α -IFN和α -IFN联合吲哚美辛治疗 6个月。治疗前后及随访半年后观察HBV -M、HBV -DNA、ALT等指标。HBV-M检测采用ELISA法 ,HBV -DNA检测采用PCR法。结果　IFN -浕 +INDO组较IFN -浕组在治疗后ＨＨＢｅＡｇ血清转阴率和ＨＢＶ-DNA血清转阴率有显著提高 ,随访半年后HBeAg血清转阴率和HBV -DNA血清转阴率在两组间仍有显著差异 ;治疗组完全应答率、部分应答率、总应答率和持续应答率均有升高 ,无应答率、复发率明显降低。结论　在慢性乙肝治疗中非甾体类抗炎药吲哚美辛确能提高IFN -浕抗病毒疗效 ,是一种提高乙肝病毒清除率的有效手段更多还原

【Abstract】 Objective To observe the curative effect of α-IFN combined with indomethacin in treating patients with chronic active HBV hepatitis. Methods 87 patients with chronic HBV hepatitis were randomly divided into 2 groups: one group received the treatment with α-IFN for 6 months(control group);the other received the joint treatment with α-IFN and Indomethacin for 6 months(expreimental group).Their levels of HBV-M, HBV-DNA and ALT were measured before treatment, after 6-month treatment and after half year follow-up and after 0.5 year follow up. Results After 6-month treatment the negative conversion rates of the HBsAg, HBeAg and HBV-DNA in the experimental group were significantly higher than those in the control group(P<0 05). After 0 5 years follows-up, the negative conversion rates of the serum HBeAg and HBV DNA still had significant differences between the two groups. In addition, the rates of complete response, partial response, total response and persistent response in the experimental group were significantly higher than those in the control group(P<0 05), which the rates of no response and relapse were significantly lower than those in the control group (P<0 05). Conclusion Indomethacin could increase the antiviral effect of INF-α in treating chronic HBV hepatitis, and is one of effective mean in improving the clear rate of HBV.更多还原