【摘要】 为了研究血液灌流用多肽吸附剂以治疗尿毒症,本文以戊二醛为交联剂,用反向悬浮聚合方法制备了交联壳聚糖吸附剂,继而用NaBH4还原处理,并对其还原效果和溶胀性能作了表征.吸附实验结果表明,吸附剂对选取的六种多肽均有不同程度的吸附;随着多肽链的增长,吸附剂对其的吸附能力体现出先增强后减小的趋势;对分子量为1100的垂体后叶素吸附效果最好.同时,吸附动力学曲线表明,随着肽分子量的增大,达到吸附平衡的时间也延长,对六种肽的吸附分别在0 6～2h内达到平衡.更多还原

【Abstract】 It is known that there are some middle molecular peptides accumulated in uremia patients’ blood. On purpose to cure uremia by hemoperfusion, the glutaraldehyde-crosslinked chitosan adsorbent was prepared by reversed-phase suspension polymerization. After reducing with NaBH₄, the adsorbent was used in adsorption experiments for peptides. The results show that the adsorption ability differs with the different molecular weight of peptides. The highest adsorption capacity is obtained with pituitrin （Mt=1100） without adsorption tendency to VB₁₂. All adsorptions reach equilibrium within 2h.更多还原