【摘要】 目的 :探讨 B细胞淋巴瘤 /白血病 - 2 (Bcl- 2 )蛋白和增殖细胞核抗原 (PCNA)蛋白与正常及异位子宫内膜的关系。方法 :应用免疫组化法检测 4 6例正常月经周期子宫内膜和 15例卵巢子宫内膜异位症患者的异位子宫内膜中的 Bcl- 2蛋白和 PCNA蛋白。结果 :Bcl- 2蛋白和 PCNA蛋白在正常月经周期子宫内膜增生期升高 (两组均为 6 1.5 % ) ,分泌期低落 (2 2 .2 %和 5 .5 % ) ,月经期消失 (0和 33.3% ) ;在异位内膜中的表达 (均为 10 0 % )高于增生期 (P<0 .0 5 )。结论 :正常月经周期子宫内膜中 Bcl- 2蛋白和 PCNA蛋白表达有周期性变化 ,且与异位子宫内膜中的表达不同 ,异位子宫内膜通过多种方式获得生存优势。更多还原

【Abstract】 Objective To study the relation between bcl-2,proliferating cell nuclear antigen (PCNA) and endometrium and endometriosis. Methods The expressions of Bcl-2 and PCNA in eutopic endometrium from 46 cases during the menstrual cycle and ectopic endometrium from 15 patients with endometriosis were examined by immunohistochemical mothod. Results The staining of Bcl-2 protein on cytoplasm of glandular cells was mainly seen in proliferative phase. It rarely appeared in secretory phase and absent during menstruation. It appeared highly in endometriosis. Conclusion The expressions of Bcl-2 protein and PCNA protein in eutopic endometrium during the menstrual cycle have periodical changes ,and differ from that in endometriosis.更多还原