【摘要】 目的 :研究三氯化铬 (Cr Cl3)对实验性糖尿病小鼠血糖的影响。方法 :将四氧嘧啶按 2 0 0 m g· kg- 1剂量腹腔内 1次性注射制作糖尿病小鼠模型。实验组分别按 4 0、 2 0和 1 0 μg· kg- 1· d- 1等 3个剂量灌服 Cr Cl3,正常对照组和实验对照组每日灌服相应体积的蒸馏水 ,实验周期均为 4周。葡萄糖氧化酶法测定空腹血糖。结果 :喂养 4周后 ,3个实验组与实验对照组比较 ,血糖水平明显降低 (P<0 .0 1 ) ,食量及饮水量减少 (P<0 .0 5或 P<0 .0 1 ) ,体重增长较快 (P<0 .0 1 )。结论 :Cr Cl3具有降低实验性糖尿病小鼠血糖的作用更多还原

【Abstract】 Objective To study the effect of CrCl 3 on blood glucose in experimental diabetic mice. Methods The model of experimental diabetic mice was established by abdominal cavity injection of alloxan with the dose of 200 mg·kg -1 . The animals were orally administered with CrCl 3, in the doses of 40,20 and 10 μg·kg -1 ·d -1 , respectively, for 4 weeks. The level of blood glucose was determined with the method of glucose oxidase. Results The body weights of mice in various treatment groups were significantly higher than that in diabetic group ( P <0 01) . The levels of blood glucose as well as the food and water intakes were obviously decreased ( P <0 05 or P <0 01). Conclusion CrCl 3 can reduce the level of blood glucose in experimental diabetic mice.更多还原