【摘要】 目的 :探讨尿α1 微球蛋白与糖尿病肾脏损害的关系及早期诊断的价值。方法 :用放免法同时检测 30例正常人和 60例 2型糖尿病 (DM)患者的α1 微球蛋白。结果 :患者组α1 微球蛋白显著高于正常组 (P <0 0 1 )。糖尿病组与对照组的α1 MG Cr(P <0 0 1 )和TRF Cr(P <0 0 5)均有明显差异。DM1组Alb Cr、β2 MG Cr与对照组无明显差异 ,而α1 MG Cr、TRF Cr有显著差异(α1 MG Cr,P <0 0 1 ;TRF Cr,P <0 0 5) ,三组α1 MG Cr、TRF Cr排泄率都明显高于健康对照组 ,且DM2 组和DM2 组明显高于DM1组 (P <0 0 1 )。结论 :尿α1 微球蛋白可作为糠尿病肾病早期诊断指标之一 ,近曲小管病变甚至早于肾小球病变更多还原

【Abstract】 Objective:To inverstigate the values of early diagnosis in diabetes injury of kidney for the urine α 1 MG.Methods:With radiotivity immunological methods,determine urine α 1 MG in 30 normal and 60 2 DM patients. Results: The levels of urine α 1 MG in 2 DM patients were observed higer than those in normal ( P <0 01). There were significant differences in α 1 MG/Cr( P <0 01) and TRF/Cr( P <0 05) between the patients and the normal.Between the DM 1 and the normal, there were no obvious differences in Alb/Cr and β 2 MG/Cr,but significant difference in α 1 MG/Cr( P <0 01) and TRF/Cr( P <0 05) .The excretion rates of α 1 MG/Cr and TRF/Cr in all three groups were higher than normal ,and those in DM 2 and DM 3 were higher than DM 1( P <0 01).Conclusion:The level of urine α 1 MG can be used as one of early diagnostic parameters in diabetes injury of kidney.更多还原