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Effect of Acupuncture on Uncoupling Protein 1 Gene Expression for Brown Adipose Tissue of Obese Rats

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【作者】 刘志诚； 孙凤岷； 赵东红； 张中成； 孙志； 吴海涛； 徐炳国； 朱苗花； 李朝军；

【Author】 LIU Zhi-cheng , SUN Feng-min , ZHAO Dong-hongZHANG Zhong-cheng, SUN Zhi, WU Hai-taoXU Bing-guo , ZHU Miao-hua , and LI Chao-jun Nanjing University of TCM, Nanjing (210029); Nanjing Population Administration College; 3. Nanjing Normal University

【机构】 Nanjing University of TCM； Nanjing 210029； Nanjing Population Administration College； Nanjing Normal University； Nanjing Normal University；

【摘要】 <正> Objective:To explore the effects of acupuncture on the expression of uncoupling protein 1（UCP1）gene of brown adipose tissue （BAT）in obese rats.Methods:The expression of UCP1 gene ofBAT was determined with RT-PCR technique.The changes of body weight,Lee’s index,body fat,andthe expression of UCP1 gene of BAT in obese rats were observed before and after acupuncture.Results:The body weight,Lee’s indeX,body fat in obese rats were all markedly higher than those in normal rats,but the expression of UCP1 gene of BAT in obese rats was all lower than that in normal rats.There werenegative correlation between the Obesity index and the expression of UCP1 gent in BAT.After acupunc-ture the marked effect of weight loss was achieved while the expression of UCP1 gene of BAT Obviously in-creased in obese rats.Conclusion:The abnormal reduction for expression of UCP1 gene of BAT might bean important cause for the obesity.To promote the expression of UCP1 in obese organism might be an im-portant cellular and mole

【Abstract】 Objective: To explore the effects of acupuncture on the expression of uncoupling protein 1 (UCP1) gene of brown adipose tissue (BAT) in obese rats.Methods: The expression of UCP1 gene of BAT was determined with RT-PCR technique. The changes of body weight, Lee’s index, body fat, and the expression of UCP1 gene of BAT in obese rats were observed before and after acupuncture. Results: The body weight, Lee’s index, body fat in obese rats were all markedly higher than those in normal rats, but the expression of UCP1 gene of BAT in obese rats was all lower than that in normal rats. There were negative correlation between the obesity index and the expression of UCP1 gene in BAT. After acupuncture the marked effect of weight loss was achieved while the expression of UCP1 gene of BAT obviously increased in obese rats. Conclusion: The abnormal reduction for expression of UCP1 gene of BAT might be an important cause for the obesity. To promote the expression of UCP1 in obese organism might be an important cellular and molecular mechanism in anti-obesity effect by acupuncture.

【关键词】 acupuncture； obesity； uncoupling protein； gene；
【Key words】 acupuncture； obesity； uncoupling protein； gene；
【基金】 The item is supported by the National Nature Science Foundation(No.39970923)
  • 【文献出处】 Chinese Journal of Integrated Traditional and Western Medicine ,中国结合医学杂志(英文版) , 编辑部邮箱 ,2003年03期
  • 【分类号】R245
  • 【被引频次】1
  • 【下载频次】64
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