【摘要】 目的比较1型糖尿病及肥胖儿童血清瘦素水平。方法以EL1SA方法测定35例1型糖尿病、32例肥胖及35例健康儿童的血清瘦素水平。35例1型糖尿病患者中 ,7例为新患糖尿病伴酮症酸中毒的患者。通过测定C -肽水平来评估胰岛素的分泌。C -肽、血糖、糖化血红蛋白按常规方法测定。结果糖尿病患者血清瘦素水平低于对照组 (P<0.001)。肥胖儿童血清瘦素及C -肽水平高于糖尿病组及对照组。在糖尿病新患者中 ,经1个月的胰岛素治疗后 ,血清瘦素水平未有任何变化 (P>0.05)。在联合组中 ,瘦素与体重指数 (bodymassindex,BMI)及C -肽呈正相关(P<0.001) ,而与血糖及糖化血红蛋白呈负相关(P<0.05)。结论1型糖尿病患儿血清瘦素水平低可能与代谢控制有关的慢性胰岛素缺乏引起的。瘦素及胰岛素在保持身体体重稳定的过程中可能起着补充作用。更多还原

【Abstract】 Objective To compare serumleptin levels in type1diabetic and obese children.Methods We measured serumleptin in35type1diabetic,32obese,and35healthy children byEL1SA.Seven of35were new-onset diabetics with ketoacidosis.C-peptide(CPE)levels were used for estimating insulin secretion.CPE、Glucose and HbA1c were measured by routine methods.Results Serum leptin levels were lower in diabetics than in controls(P<0.001).Obese children had higher leptin and CPE levels than diabetics and controls.In new-onset diabetics,1month insulin treatment did not cause any change in leptin levels(P>0.05).Leptin was correlated positively with body mass index and CPE(P<0.001)and negatively with glucose and HbA1c(P<0.05)in the combined group.Conclusions Low serum leptin levels in type1diabetic children may be due to chronic insulin deficiency related to their metabolic control.Leptin and insulin may have complementary roles in maintaining a stable body weight.更多还原