【摘要】 [目的]研究萘普生(naproxen)/聚乙二醇-聚谷氨酸苄酯共聚物(PEG-PBLG)纳米胶束的制备、形态和体外释药规律。[方法]合成了PEG-PBLG两亲嵌段共聚物;采用透析法制备了萘普生/PEG-PBLG载药胶束;通过透射电镜观察、动态光散射测定、紫外吸光度测定等手段分析胶束的微观形态、粒径大小和载药量、测定了载药胶束的体外释药速率。[结果]萘普生/PEG-PBLG载药胶束粒径在30～245 nm范围,胶束呈核-壳型结构,PEG-PBLG胶束可大大增溶疏水性药物,萘普生/PEG-PBLG胶束具有缓释作用,萘普生的体外释放速率大小主要由介质的pH值决定,也受胶束粒径的影响。[结论]PEG-PBLG载药胶束是一种缓释性能良好、有应用前景的纳米胶束。更多还原

【Abstract】 [Objective] To study the preparation of Naproxen/poly(ethylene glycol)-poly(benzyl L-glutamate) copolymer micelles,their morphology and drug release characteristics in vitro. [Methods] The poly(ethylene glycol)-poly(benzyl glutamate) amphipathic copolymers were synthesized, Naproxen/PEG-PBLG copolymer micelles were prepared by dialysis method. Microscopic morphology, diameter and drug-loaded amount of the micelles were examined by means of TEM, DLS and UV respectively, and their in vitro drug release rates were measured. [Results] The diameters of micelles were in the range of 35-245 nm, and the core-shell structure existed in the micelles, PEG-PBLG copolymer micelles could solubilize hydrophobic drugs. In vitro Naproxen sustained release from micelles was observed. [ Conclusion ] Drug/PEG-PBLG copolymer micelles display perfect drug-release performance and can be potentially used as a new nano-pharmaceutical carrier.更多还原