【摘要】 目的　探讨贲门癌发生的危险因素。方法采用病例对照研究方法 ,研究对象 5 82例 ,其中贲门癌新病例 2 91例 ,对照 2 91例。应用统一制订的调查表进行流行病学调查。对资料进行单因素和多因素Logistic回归分析。 结果　贲门癌的危险因素有 :三餐不按时 (OR =1.4 4,95 %CI :1.15 1.81)、进食快 (OR=1.4 0 ,95 %CI :1.0 9 1.80 )、食用猪油 (OR =1.6 7,95 %CI :1.19 2 .35 )、饮用井水 (OR =1.90 ,95 %CI :1.2 7 2 .84 )、吸烟 (OR =1.2 8,95 %CI :1.0 5 1.5 8)和家庭肿瘤史 (OR =3.15 ,95 %CI :1.97 5 .0 4 )。常吃新鲜蔬菜(OR =0 .5 3,95 %CI :0 .2 8 0 .99)、水果 (OR =0 .75 ,95 %CI :0 .5 6 1.0 0 )、牛奶 (OR =0 .5 2 ,95 %CI :0 .2 9 0 .93)及文化程度高者 ,其胃癌发生风险低。结论　本研究首次发现不良的饮食方式是贲门癌的危险因素 ,对肿瘤预防有重要意义。更多还原

【Abstract】 Objective To investigate the potential risk and protective factors of gastric cardia cancer.Methods A case control study in Fujian Province was conducted, which including 291 cases with cardia cancer and 291 controls. Standard questionnaire were used in collecting epidemiological factors. The data was analyzed by Logistic regression model. Results Increased risk of cardia cancer was associated with irregular meal time(OR=1.44,95%CI:1.15 1.81),eating too fast(OR=1.40,95%CI:1.09 1.80), lard oil intake(OR=1.67,95%CI:1.19 2.35), well water drinking(OR=1.90,95%CI:1.27 2.84), cigarette smoking(OR=1.28,95%CI:1.05 1.58)and family history of cancer(OR=3.15,95%CI:1.97 5.04). Inverse associations were also observed between fresh vegetables(OR=0.53, 95%CI:0.28 0.99), fruits(OR=0.75,95%CI:0.56 1.00), milk (OR=0.52,95%CI:0.29 0.93), higher socio economic statusand cardia cancer. Conclusions This is the first time that the eating patterns are identified as risk factors for cardia cancer in a Chinese population, which may be of importance in prevention of the disease.更多还原