【摘要】 目的　探讨健康志愿者急性酒精摄入后肝酶谱、心肌酶谱的变化及意义。方法　健康志愿者单次摄入 182ml白酒 (含纯酒精 80g)后 ,分别于饮酒结束起 0 5、1、1 5、2、2 5、3、6、2 4h用呼气测醉仪测定血酒精浓度及外周血肝酶谱、心肌酶谱的实验室指标。结果　健康志愿者单次摄入含80 g纯酒精的白酒后 ,血酒精浓度于 1h后达到峰值 ,后不断下降 ,至 2 4h后恢复正常 ;与血酒精浓度为 0g/L时相比 ,丙氨酸氨基转移酶 /门冬氨酸氨基转移酶 (ALT/AST)比值于血酒精浓度大于 1 2g/L时显著升高 (1 2 8、0 94 ,P <0 0 5 ) ;碱性磷酸酶和谷胺酰转肽酶于血酒精浓度为 0～ 0 4 g/L时显著升高 [分别为 (84 0± 15 1)U/L、(6 7 9± 18 6 )U/L、(2 7 1± 16 3)U/L、(13 8± 11 5 )U/L ,P<0 0 1];肌酸激酶同工酶升高和羟丁酸脱氢酶降低 [于血酒精浓度大于 1 2 g/L时较 0g/L时分别为 :(13 2± 2 1)U/L、(5 9± 2 8)U/L ;(2 7 1± 5 0 )U/L、(37 5± 5 5 )U/L ,P <0 0 5 ]。结论急性酒精中毒可引起健康志愿者肝脏相关酶类及心肌酶谱指标改变 ,造成肝脏、心肌一过性损害。更多还原

【Abstract】 Objectives To observe the change of the index of hepatic enzymes and myocardial enzymes and realize the effect of acute alcohol intake on liver and myocardium in human body. Methods Select 15 social healthy volunteers, 182 ml white wine (contained 80 g ethanol ) was taken in a time. After drown up, venous blood example were collected at the interview of 0.5,1,1.5,2,2.5,3,6,24 hour. Blood alcoholic level were detected with Lion alcolmeter, and the index of hepatic enzymes and myocardial enzymes were detected by the blood sample. Results After the intake of 80 g ethanol contain wine, the value of blood alcohol concentration reach the peak value at 1 hour, then decrease to normal in 24 hour. Contrast to the alcoholic concentration of 0 g/L, the value of ALT/AST significantly increased when the alcoholic concentration higher than 1.2 g/L(1.28 vs 0.94,P<0.05), and the value of AKP and γ-GT were higher when alcoholic concentration reach 0～0.4 g/L(were 84 vs 67 U/L and 27.1 vs 13.8 U/L respectively, P<0.01). CKMB increased and HBDH decreased predominantly when the alcoholic concentration higher than 1.2 g/L (were 13.2 vs 5.9;27.1 vs 37.5 U/L respectively,P<0.05).Conclusion Acute alcohol intoxication canchange the laboratory index of hepatic enzymes list and myocardial enzymes list. And cause reversible injury of liver and myocardium.更多还原