【摘要】 目的　研究adiponectin在冠心病、高血压、糖尿病和单纯性肥胖病人血清中的水平。方法　采用双抗夹心酶联免疫试验测定血清中adiponectin水平。结果　共测定 6 0名正常人 ,30例冠心病患者 ,2 2例高血压患者 ,32例糖尿病患者和 47例单纯性肥胖病人。adiponectin水平分别为 :冠心病组 ( 3 90± 1 36 )mg/L、高血压组 ( 3 6 1± 3 0 0 )mg/L、糖尿病组 ( 4 14± 2 19)mg/L、单纯性肥胖组( 4 0 2± 2 5 2 )mg/L与正常对照组 ( 9 82± 2 99)mg/L之间的差异均具有统计学意义 (P <0 0 1)。结论　adiponectin在冠心病组、高血压组、糖尿病组和单纯性肥胖组中的水平下降 ;低adiponectin水平可能是肥胖致相关疾病的分子生物学基础之一。更多还原

【Abstract】 Objective To study and compare the serum level of adiponectin in patients with coronary artery disease (CAD), hypertension, diabetes mellitus and obesity.Methods The serum concentration of adiponectin was determined by ELISA.Results adiponectin level in healthy volunteers (9.82±2.99) mg/L had a statistical difference to that of patients with CAD (3.90±1.36) mg/L, hypertension (3.61±3.00) mg/L, diabetes mellitus (4.14±2.19) mg/L and obesity (4.02±2.52) mg/L ( P<0.01).Conclusion The serum level of adiponectin was low in patients with CAD, hypertension, diabetes mellitus and obesity. It suggests that adiponectin may be one of the molecular biological bases of the pathogenesis between obesity and obesity-linked disorders.更多还原