【摘要】 目的检测博尔纳病病毒(BDV)对中国慢性疲劳综合征(CFS)患者和健康对照者感染的情况,探讨CFS与BDV感染之间的相关性。方法按美国CDC 1994年标准,搜集来自全国十一省市的CFS患者61例和健康对照73例,使用蛋白印迹法(WB)对其血浆进行BDV-p24抗体检测。结果 病例组有7例为阳性结果(11.48％),对照组均为阴性(0％),统计学处理两组间差异有显著意义(P<0.010)。结论中国CFS患者存在BDV感染,病例组感染率明显高于对照组,CFS与BDV感染存在相关性。更多还原

【Abstract】 Objective To evaluate the prevalence of infection with Borna disease virus (BDV) in Chinese patients with chronic fatigue syndrome (CFS) and control subjects, and to discuss the etiological association between CFS and infection with BDV. Methods The CDC (1994) diagnostic criteria for CFS were used for case definition. Sixty-one patients suffered from CFS were from 11 Provinces in China. To detect the antibody against BDV-p24 on the plasma samples from all cases and 73 healthy control subjects by Western-blotting analysis. Results 7 of the Sixty-one cases and 0 of the controls were sero-positive for BDV-p24 antibody, there was a statistical significant difference between the two groups (11.48% vs 0% ; P < 0.010) . Conclusion Chinese patients with CFS showed sero-positive identifying BDV infection, by comparison, anti-BDV-p24 antibody prevalence in patients was significantly higher than in controls. An etiological association may exist between CFS and BDV infection.更多还原