【摘要】 目的　研究核转录因子 (NF κB)及白细胞介素 (IL) 8在人胃癌组织中表达与胃癌血管形成及预后的关系。方法　免疫组化法检测 4 1例胃癌组织中核转录因子NF κB、IL 8表达和微血管密度(MVD)。结果　 4 1例胃癌中NF κB和IL 8的阳性表达率分别为 6 8.3% (2 8例 )和 2 9.3% (12例 ) ,前者与MVD显著相关 (P =0 .0 0 2 ) ,但后者与MVD表达无关。NF κB和IL 8与TNM分期显著相关 (P<0 .0 5 ) ,阳性者多为进展期胃癌 ,而且表达阴性组预后均明显优于阳性组 (P <0 .0 5 )。结论　NF κB/IL 8旁路调控可能不是胃癌组织内的主要促血管生成途径 ,NF κB和IL 8阳性表达反映胃癌的恶性程度 ,并可作为判断预后的参考指标。更多还原

【Abstract】 Objective To disclose the implication of nuclear transcription factor(NF)-κB and interleukin(IL-8) in the angiogenesis and prognosis of gastric cancer. Methods The expressions of NF-κB, IL-8 and microvessel density (MVD) in 41 samples of gastric cancer were detected by immunohistochemistry. Results NF-κB and IL-8 were positive in 28 samples (68.3%) and 12 samples (29.3%) respectively. NF-κB, but not IL-8, was related to MVD significantly( P =0.002), and there was significant relationship between the expressions of NF-κB and IL-8 and TNM staging( P <0.05), with most of positive samples in advanced stage. Furthermore, the prognosis of NF-κB and IL-8 negative patients was better than their NF-κB positive counterparts( P < 0.05 ). Conclusion Bypass regulation of NF-κB/IL-8 may be not one of the main pathways更多还原