【摘要】 过氧化物酶体增殖剂活化受体γ(PPARγ)是一个由配体激活的核转录因子 ,属于核激素受体 (nuclearhormonereceptor)超家族。被激动剂激活以后 ,该受体可以促进葡萄糖的利用以及胰岛素的增敏。因此 ,PPARγ激动剂有希望成为一类全新的Ⅱ型糖尿病治疗药物。本文对现有的PPARγ天然和合成的激动剂进行一个综述更多还原

【Abstract】 Peroxisome proliferator activated receptor γ (PPAR γ )is a very important ligand activated nuclear transcription factor,belonging to nuclear hormone receptor superfamily.Activated by agonists,the receptor plays a crucial role in glucose utilization and insulin sensitization.PPAR γ agonists are therefore expected to be novel drugs for the treatment of type Ⅱ diabetes.In this article,the development of natural and synthetic PPAR γ agonists is reviewed.更多还原