【摘要】 目的　探讨NO、ET和脂质过氧化在妊高征中的作用。方法　对 2 3例中、重度妊高征患者血浆中NO的稳定代谢产物亚硝酸盐 /硝酸盐 (NO-2 /NO-3)、ET 1、MDA水平及SOD活性进行测定。结果　中、重度妊高征组与正常晚期妊娠组比较 ,各指标均有显著性差异 (P <0 0 1) ;妊高征患者NO/ET值与SOD/MDA值呈显著正相关 (r =0 895 0 ,P <0 0 1) ;而MAP与NO/ET值呈显著负相关 (r =- 0 844 7,P <0 0 1)。结论　妊高征发生可能与脂质过氧化损伤所引起的NO/ET比例失调有关更多还原

【Abstract】 Objective To study the role of NO,ET and lipid peroxidation in pregnancy induced hypertension.Methods The plasma NO - 2/NO - 3,ET 1,MDA concentrations and SOD activity were examined in 23 PIH patients,20 normal pregnant women and 20 normal non pregnant women.Results There were significant changes of all indexes between moderate,severe PIH groups and normal pregnant group (P<0 01);There was apparently positive correlation between the NO/ET and SOD/MDA value (r=0 8950,P<0 01),while apparently negative correlation between MAP and NO/ET value (r=-0 8447,P<0 01).Conclusion The occurrence of PIH is related to the imbalance of NO/ET induced by the lipid peroxidation.更多还原