【摘要】 目的探讨丹参注射液治疗颅脑损伤后脑水肿及颅内压增高的最佳作用阶段。方法选择98例颅脑损伤,随机分为超早期(伤后6～12h,T1)、早期(伤后24～72h,T2)给药组及对照组(C)。给药组加用丹参注射液,观察各组伤后第1、3、5、7天颅内压(ICP)及第7、14天脑水肿情况,并加以比较。结果T1组伤后第3、5、7天ICP均明显低于C组(P<0.05),T2组至第7天ICP才明显低于C组(P<0.05)。伤后第7天重度脑水肿比率T1组明显低于C组(P<0.05),T2组与C组无显著性差异(P>0.05);第14天脑水肿消退比率T1组及T2组均明显高于C组(P<0.05),但T1组更加明显(P<0.01)。结论超早期应用丹参注射液将更有利于减轻颅脑损伤后脑水肿及降低脑水肿所致高颅内压。更多还原

【Abstract】 Objective To investigate the most effective stage of treating brain edema and intracranial hypertension with salvia miltiorrhiza injection in the patients with brain injury.Methods Ninty-eight patients with brain injuries were selected for the present study and divided randomly into three groups,i.e.treatment group6～12hours(ultra-early)after the injury(T 1 ),treatment group24～72hours(early)after the injury(T 2 )and control group(C).The patients in the C group were only conventionally treated and the patients in T 1 and T 2 group were treated by the conventionally treated and salvia miltiorrhiza injection.The intracranial pressure(ICP)were determined by lumbar puncture the1st,3rd,5th and7th days after the injury and the brain edema was observed by CT scan the7th and14th days after the injury in the patients of every group.Results The ICP in T 1 group the3rd,5th and7th days after the injury and in T 2 only the7th day after the injury was significantly lower than that in C the same time after the injury.The percentage of the patients with severe brain edema in T 1 group the7th day after the injury was significantly lower than that in C group(P<0.05).There was the insignificant difference in the percentage of the patients with severe brain edema between T 2 and C groups.The percentage of the patients with no brain edema in T 1 (P<0.01)and T 2 (P<0.05)groups were significant higher than that in C group.Conclusions Using salvia miltiorrhiza injection at the ultra-early stage was very beneficial to lightening the degree of brain edema and to lowering the intracranial hypertension caused by the edema in the patients with brain injury.更多还原