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低强度脉冲超声对关节软骨缺损修复影响的初步观察

Primary Observation of Low Intensity Pulsed Ultrasound on Repair of Articular Cartilage Defect

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【作者】 贾小林陈文直周伟王智彪

【Author】 Jia Xiaolin,Chen Wenzhi,Zhou Wei,et al Institute of Ultrasonic Engineering in Medicine, Chongqing University of Medic al Sciences,Chongqing400016China

【机构】 重庆医科大学医学超声工程研究所重庆医科大学医学超声工程研究所 400016重庆市400016重庆市

【摘要】 目的 :观察低强度脉冲超声对兔膝关节软骨缺损修复的影响。方法 :于 3 0只兔股骨髁间窝软骨面处钻孔 ,术后左后肢膝关节缺损处以低强度脉冲超声辐照 ,右后肢予以假照作为对照。分别于术后 2周、 4周和 8周处死 ,作大体及病理组织学观察。结果 :大体观察和组织学观察均表明治疗组修复比对照组提前 ,且修复组织中蛋白多糖含量明显增加。结论 :低强度脉冲超声能促进关节软骨缺损修复

【Abstract】 Objective:To investigate the effects of low intensity pulsed ultrasound (LIPU) on articular cartilage defects.Methods:Thirty healthy white New Zealand adult rabbits wi th bilateral,full-thickness osteochondral defects in the cartilage surfaces of intercondylar fossas were used.The left knees in these animals were treated.The right knees were sham-treated.Groups of 10 animals were sacrificed at 2,4 and 8 weeks postoperatively.Results:Both gross and histological appearances showed th e tissue repair of the experimental sides was quicker than those of the control sides.Conclusions:Our paper indicated that LIPU can accelerate a rticular cartilage defect repair.

【基金】 国家“九五”重点科技攻关项目( No. 96 - 90 5-0 2 - 0 1 );国家自然科学基金重点项目( No. 396 30 34 0 )资助
  • 【文献出处】 中国超声医学杂志 ,Chinese Journal of Ultrasound In Medicine , 编辑部邮箱 ,2003年12期
  • 【分类号】R454.3
  • 【被引频次】16
  • 【下载频次】115
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