【摘要】 目的 研究肉苁蓉多糖（CDP）对肺衰老模型的细胞凋亡、一氧化氮（NO）含量及超氧化物歧化酶（SOD）活力的作用及作用机制。方法 取2 mon龄小鼠常规条件下饲养11 mon,制成自然衰老模型,用CDP 25、50、100 mg·kg^-1分别灌服衰老小鼠6 wk,检测衰老小鼠血清及肺组织中NO浓度及SOD活性,借助荧光显微镜研究肺组织细胞凋亡的形态学变化。结果 衰老可引起血清及肺组织SOD活性降低、NO含量升高,还可诱导肺组织细胞凋亡。CDP可以明显提高机体血清和肺的SOD活力、降低NO浓度,明显抑制了肺组织细胞凋亡,使细胞数减少,凋亡百分率（APO％）降低。结论 CDP对衰老小鼠肺组织细胞的退行性变化具有改善或延缓作用。更多还原

【Abstract】 AIM To evaluate the effect of METHODS 2 month-old mice were fed routinelycistanche desertica polysacchrides(CDP) on the ni- for 11 mounths to establish the model of naturallytric oxids(NO) ,superoxide dismutase(SOD) in se- aging mice. The cistanche desertica polysacchridesrum and apoptosis of lung cell in aging mice. 25, 50, 100 mg ?kg~’ were administrated respec- lively to the mice po. then investigated the concentration of NO, SOD and the morphological changes of apoptosis by fluoromicroscope. RESULTS Aging could induce the lung cell apoptosis, decrease the level of SOD, and increase the level of NO as well. The cistanche desertica polysacchrides signif- icantly ameliorated the lung cell apoptosis; decreased the level of NO, improved the activity of SOD. CONCLUSION Cistanche desertica polysac-chrides have ameliorating and postponing effects on the regressive changes in the lung of aging mice.更多还原